MINNEAPOLIS (KMSP) - Researchers at the University of Minnesota say they have made a discovery that could change the landscape for women with breast cancer, or even those who may get the disease down the road.
The U of M team found a human enzyme responsible for causing DNA mutations found in the majority of breast cancers.
The discovery of this enzyme -- called APOBEC3B -- may change the way breast cancer is diagnosed and treated.
"We strongly believe this discovery will change the way mutations in cancer are viewed and, hopefully, it will allow cancer researchers to develop new treatments approaches that can prevent these mutations before they become harmful," said Dr. Reuben Harris, an associate professor of biochemistry, molecular biology and biophysics at the University of Minnesota.
Dr. Harris stressed that additional research is still needed, but if further studies confirm high levels of the enzyme do indicate the early presence of breast cancer, a simple blood test could be a strategy for early detection.
This research actually began through a $10 million grant to study treatment for HIV and other viral diseases.
Through his team's research, Harris was able to conclude that this one enzyme is a key influencer in breast cancer.
"DNA mutations are absolutely essential for cancer development," Harris said. "Our experiments showed the APOBEC3B enzyme causes mutations in the genome of breast cancer cells. From this, we were able to reasonably conclude that the APOBEC3B is a key influencer in breast cancer."
However, Harris says APOBEC3B appears to be a biological "double-edged sword," protecting some cells from viruses such like HIV while producing mutations that give rise to cancer in others.
"Our next steps will focus on the connections between high levels of APOBEC3B, age and other genetic risk factors that are known breast cancer markers. Ultimately, we hope our discovery leads to better therapeutic outcomes for patients," said Harris.
The research appears in the latest edition of Nature.
Tuesday, May 21 2013 10:17 AM EDT2013-05-21 14:17:24 GMT
When it comes to talking to doctors, a lot of us aren't exactly shooting straight. In fact, one survey found that almost 30 percent of patients admit to lying to their physician.
When it comes to talking to doctors, a lot of us aren't exactly shooting straight. In fact, one survey found that almost 30 percent of patients admit to lying to their physician. So, how much does your doctor really need to know?
Monday, May 20 2013 6:03 PM EDT2013-05-20 22:03:26 GMT
Sutton Burnett's blog began as a way to share her story with friends and family. It's grown into something much deeper.
Drop in on your friend's Facebook pages and blogs and you'll probably see a lot of photos of their kids. Sutton Burnett's blog began as a way to share her story with friends and family. It's grown into something much deeper.
Friday, May 17 2013 6:28 PM EDT2013-05-17 22:28:40 GMT
Melanoma is considered the deadliest form of skin cancer. A veteran dermatologist says he used to see three to five melanomas a year. Now, he says, he sees that many in a week!
Melanoma is considered the deadliest form of skin cancer. A veteran dermatologist says he used to see three to five melanomas a year. Now, he says, he sees that many in a week!
Thursday, May 16 2013 11:00 PM EDT2013-05-17 03:00:47 GMT
A new report from the Centers for Disease Control and Prevention shows millions of American kids suffer from mental health problems. Experts believe as many as 20 percent of American children are affected.
A new report from the Centers for Disease Control and Prevention shows millions of American kids suffer from mental health problems. Experts believe as many as 20 percent of American children are affected.
Thursday, May 16 2013 12:02 AM EDT2013-05-16 04:02:20 GMT
Hundreds of American troops have lost a leg or arm in Afghanistan because of improvised explosive devices or homemade bombs.
Hundreds of American troops have lost a leg or arm in Afghanistan because of improvised explosive devices or homemade bombs. It was 29-year-old John Kremer's job to find those hidden bombs, and safely destroy them. That's what the Buford man was trying to do, when one of them exploded right under his feet.
Wednesday, May 15 2013 6:42 PM EDT2013-05-15 22:42:54 GMT
"You're fired!" Those are two words you never want to hear from anyone, especially your own doctor. But that can happen when patients and physicians don't see eye-to-eye.
"You're fired!" Those are two words you never want to hear from anyone, especially your own doctor. But that can happen when patients and physicians don't see eye-to-eye.
Tuesday, May 14 2013 7:48 AM EDT2013-05-14 11:48:46 GMT
There are more than 31 million Americans enrolled in Medicare Part D. And according to a recent survey, more than a third are worried about prescription drug costs.
There are more than 31 million Americans enrolled in Medicare Part D. And according to a recent survey, more than a third are worried about prescription drug costs.
1551 Briarcliff Rd., NE Atlanta, GA 30306
Main Number: (404) 875-5555 News Tips: (404) 898-0100
